HealthScience

The ibuprofen can cause damage to male fertility?

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At first glance, the data concerned: the ibuprofen, the active ingredient of many anti-inflammatory-the-counter, it would result in the so-called hypogonadism offset in the man, a common condition of the elderly that is associated with a decline in fertility and other disorders.

It supports a small study published in the Proceedings of the National Academy of Sciences, according to which the problem would occur in young men therapy with ibuprofen. Experts, however, invite you to the caution: the need for confirmations, the “therapy” magazine has provided higher doses and for longer times compared to the usual.

At first glance, the data concerned: the ibuprofen, the active ingredient of many anti-inflammatory-the-counter, it would result in the so-called hypogonadism offset in the man, a common condition of the elderly that is associated with a decline in fertility and other disorders.

It supports a small study published in the Proceedings of the National Academy of Sciences, according to which the problem would occur in young men therapy with ibuprofen. Experts, however, invite you to the caution: the need for confirmations, the “therapy” magazine has provided higher doses and for longer times compared to the usual.

A number of tests

 

The study involved only 31 healthy volunteers was given a placebo or ibuprofen at a dose of 600 milligrams twice a day, for six weeks; at the end were performed hormone tests on the blood. In the meantime, were also conducted examinations on the tissue of the testis taken from patients with prostate cancer, not previously treated with hormones, the fabric, exposed or not to different doses of ibuprofen, was then analyzed to understand if and how it changed the expression of some genes and the production of hormones.

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Finally, tests of the same kind have also been conducted on a human cell line in culture.The results indicate that the anti-inflammatory alters the hormonal balance of the male, leading to an increase of the hormone luiteinizzante (LH, that which in man stimulates the testis to produce testosterone) and a decline in the ratio between testosterone and LH, indicating a state of hypogonadism offset: in this condition, fairly common in the third age, the testosterone remains at levels almost normal, but gradually testicular function is reduced and may appear fertility problems.

Preliminary data, serves prudence

The data that emerged from the analysis on the testes isolated and the cells confirm that the ibuprofen in the long run may lead to changes in the production of testosterone, through a selective repression of the expression of some genes that would lead to the hormonal imbalance, with the increase of LH and hypogonadism plywood.

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Sad Pills

The correlation has emerged for the first time and according to the authors, is worthy of note given the continuous increase in the frequency of male infertility.Pierangelo Geppetti, pharmacologist and director of the Department of Health Sciences of the university of Florence, emphasizes, however, that worry is premature: “The study on volunteers is small and therefore will need to be replicated, but, above all, doses and times of administration of the ibuprofen are not very “realistic”: the daily dosage of 1200 mg is high and it will be hard to reach, plus it’s unlikely that a therapy similar will be followed up for more than a month.

It is to take six times a day a pill of pain reliever, because in the most common formulations-the-counter these products contain 200 milligrams of ibuprofen: an abuse of the therapy that we see infrequently, usually in migraine patients and more often in women. It is appropriate to investigate yet, so, but with a reasonable use you should not take any risks”.

A number of tests

The study involved only 31 healthy volunteers was given a placebo or ibuprofen at a dose of 600 milligrams twice a day, for six weeks; at the end were performed hormone tests on the blood. In the meantime, were also conducted examinations on the tissue of the testis taken from patients with prostate cancer, not previously treated with hormones, the fabric, exposed or not to different doses of ibuprofen, was then analyzed to understand if and how it changed the expression of some genes and the production of hormones.

Finally, tests of the same kind have also been conducted on a human cell line in culture.The results indicate that the anti-inflammatory alters the hormonal balance of the male, leading to an increase of the hormone luiteinizzante (LH, that which in man stimulates the testis to produce testosterone) and a decline in the ratio between testosterone and LH, indicating a state of hypogonadism offset: in this condition, fairly common in the third age, the testosterone remains at levels almost normal, but gradually testicular function is reduced and may appear fertility problems.

Preliminary data, serves prudence

The data that emerged from the analysis on the testes isolated and the cells confirm that the ibuprofen in the long run may lead to changes in the production of testosterone, through a selective repression of the expression of some genes that would lead to the hormonal imbalance, with the increase of LH and hypogonadism plywood.

The correlation has emerged for the first time and according to the authors, is worthy of note given the continuous increase in the frequency of male infertility.Pierangelo Geppetti, pharmacologist and director of the Department of Health Sciences of the university of Florence, emphasizes, however, that worry is premature: “The study on volunteers is small and therefore will need to be replicated, but, above all, doses and times of administration of the ibuprofen are not very “realistic”: the daily dosage of 1200 mg is high and it will be hard to reach, plus it’s unlikely that a therapy similar will be followed up for more than a month.

It is to take six times a day a pill of pain reliever, because in the most common formulations-the-counter these products contain 200 milligrams of ibuprofen: an abuse of the therapy that we see infrequently, usually in migraine patients and more often in women. It is appropriate to investigate yet, so, but with a reasonable use you should not take any risks”.